Muthu Alagappan, founder and CEO of Counsel Health, joins Julie Yoo, a16z Bio + Health general partner, to dive deep into the company's vision for revolutionizing healthcare through AI-powered asynchronous care. Together, they unpack how Counsel enables on-demand access to real doctors for instant medical guidance, lessening patient reliance on Google and alleviating system inefficiencies and physician burn-out. Muthu also explores the duo of efficiency and scale that large language models bring to clinical workflows, making its “clinician cockpit” a superhuman support system for physicians.

More in "The Opportunity for Healthcare in a Post-LLM World":

• Voice AI: Solving Healthcare's Workforce Challenges with Ankit Jain
• Super Staffing in Healthcare with Munjal Shah
• Transforming Clinical Trials with Alexander Saint-Amand

Plus:

• Learn more about a16z Bio+Health
• Learn more about & Subscribe to Raising Health
• Find a16z Bio+Health on LinkedIn
• Find a16z Bio+Health on X

Ankit Jain, CEO and cofounder of Infinitus Systems, Inc, joins Julie Yoo, a16z Bio + Health general partner, to discuss Infinitus's work in solving one of healthcare's most pressing challenges: workforce shortages. Leveraging LLMs and AI voice agents, Infinitus automates repetitive tasks, such as benefits verification and prior authorization, freeing up human talent for higher-value roles. Ankit reflects on the company’s journey—from early proof-of-concept calls to scaling over five million patient-centric interactions—and shares their approach to mitigating the risks of AI errors through layered guardrails.

More in "The Opportunity for Healthcare in a Post-LLM World":

• Super Staffing in Healthcare with Munjal Shah
• Transforming Clinical Trials with Alexander Saint-Amand

Plus:

• Learn more about a16z Bio+Health
• Learn more about & Subscribe to Raising Health
• Find a16z Bio+Health on LinkedIn
• Find a16z Bio+Health on X

Alexander Saint-Amand, cofounder and CEO of Topography, reflects on his journey from leading Gerson Lehrman Group (GLG), a pioneer in expert networks, to tackling systemic barriers in clinical trials at his current company, Topography. Inspired by personal experiences, Alexander’s mission centers on democratizing access to clinical research by transforming community-based practices into thriving hubs for trials. Alongside a16z Bio + Health general partner Julie Yoo, he discusses the pervasive challenges in enrollment, physician participation, and the inefficiencies plaguing the current model.

Alexander also talks through Topography's hybrid approach—combining technology, services, and AI—and its potential to lower the barrier to entry for providers, improving patient access.

Rajaie Batniji, MD, PhD, Afia Asamoah, JD, and Sanjay Basu, MD, PhD, cofounders of Waymark, join Vineeta Agarwala, MD, PhD, a16z Bio + Health general partner, to discuss their transformative approach to Medicaid care delivery. This episode dives into their rising risk signal prediction framework, where cutting-edge machine learning predicts patient needs and enables community-based care teams to reduce preventable ER visits and improve health outcomes at scale.

The team recently published their real-world results—including a 23% reduction in unnecessary acute care—in the New England Journal of Medicine Catalyst.

Additional resources:

• Supporting Rising-Risk Medicaid Patients Through Early Intervention, NEJM Catalyst
• The Body Economic: Why Austerity Kills, by David Stuckler and Sanjay Basu

Hippocratic AI cofounder and CEO Munjal Shah joins a16z Bio + Health general partner Julie Yoo to explore the incredible potential of generative AI in transforming healthcare delivery. Together, they discuss the emerging "voice renaissance" in healthcare, the nuances of designing safe and empathetic AI interactions, and how Hippocratic AI is addressing safety concerns with innovations like multi-LLM architecture and rigorous training with thousands of nurses.

This episode also discusses a shift toward viewing AI tools as an opportunity for healthcare "super staffing," and strategies for integrating AI into complex healthcare systems.

Jeff Margolis, founder of TriZetto, joins Julie Yoo, a16z Bio + Health general partner, to share the journey of building an iconic company in healthcare infrastructure. From the early days of managed care to creating a three-pronged platform uniting computing power, software, and data analytics, Jeff reflects on TriZetto’s groundbreaking model that reshaped payer-provider transactions and set industry standards. Together, they also delve into the strategic importance of scaling through acquisitions, aligning with industry standards, and crafting innovative pricing models.

In this episode, Matt Wilsey joins Jorge Conde to share the profound personal story of his daughter Grace's diagnosis with NGLY1 deficiency and how it catalyzed his journey to founding a biotech startup, Grace Science, aimed at developing a cure for his daughter’s condition.

Matt emphasizes the importance of strategic partnerships, like his collaboration with Nobel laureate Carolyn Bertozzi, and sheds light on the search for gene therapies for rare diseases.

Check out our previous episode with Carolyn Bertozzi here.

Nobel laureate Carolyn Bertozzi joins Jorge Conde to unravel the concept of bioorthogonal chemistry.

Carolyn traces her pioneering path from early studies in carbohydrate chemistry to how her lab developed the revolutionary ability to manipulate chemical reactions inside the human body.

Together, they highlight the intersection of cutting-edge academic research and the challenges of translating discoveries into market-ready solutions. They also discuss navigating the science-to-startup journey, balancing academic and commercial ambitions, and leveraging precision therapies to address unmet medical needs in cancer and beyond. It’s a compelling case study for founders looking to push the frontiers of biotech.