Matt Maiocco and Jennifer Lee Chan discuss who can replace rookie running back Isaac Guerendo's production if he can't overcome his sprained foot on a short week. Under the microscope this week, can Deebo Samuel shed the criticism and help the 49ers' offense repeat its high-octane performance vs. Chicago, or will backup Patrick Taylor Jr. emerge from anonymity as the 5th-string running back this season for San Francisco. Later, Matt and Greg Papa discuss how the 49ers' adjust their game plans and practice schedules on a short week and the possibility of linebacker Dre Greenlaw making his 2024 season debut in Week 15 vs. the Rams.

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(1:00) Must win territory, have to play desperation football
(3:30) Deebo a big topic of conversation this week, production down, but big opportunity in Week 15
(13:00) Injury Update – Big three going into this week Guerendo, Bosa, Trent are questionable
(14:00) Runnings back room depth chart
(17:00) If Greenlaw returns there will be a boost in the stands and on the field
(27:00) 18 teams in the NFL run Kyle’s offense now

Matt Maiocco and Jennifer Lee Chan analyze how the 49ers got back to their winning ways against the Bears behind an explosive offense and dominant defense. Matt and Jennifer discuss rookie running back Isaac Guerendo's two-touchdown performance and how the run game will shape up on a short week. Also, Matt and Jennifer look ahead to the 49ers' Thursday night showdown with division rival LA Rams and how San Francisco can get back to .500.

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(1:00) Recapping rookie RB Isaac Guerendo’s impressive performance
(4:15) Ji'Ayir Brown odd-man out of secondary with Hufanga back
(11:30) Injury updates on Guerendo's ankle, OL Ben Bartch's ankle
(17:30) Taking inventory of rest of NFC West Division results, remaining schedules
(21:30) Deommodore Lenoir's surprise team speech, showing leadership
(24:00) Rest of the season is about not spiraling into the offseason

Matt Maiocco and Jennifer Lee Chan break down the 49ers' injury crisis and which players will need to step up on Sunday and for the rest of the season. Also, Kyle Shanahan sits down with Greg Papa to detail what to expect from Isaac Guerendo and break down how San Francisco will defend Caleb Williams and the the Chicago Bears.

With the 49ers’ top two running back options headed to injured reserve, Matt Maiocco and Jennifer Lee Chan discuss rookie Isaac Guerendo's big opportunity to fill the starting role for the final five weeks of the season. Also, Matt and Jennifer look ahead to next season as performances in the final stretch could affect how the 49ers view their options at offensive line and running back next season. Later, Jennifer and Greg Papa dissect how the 49ers can still make a run at the playoffs, starting with a Week 14 matchup against the Chicago Bears on Sunday at Levi's Stadium.

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(2:00) 49ers must retool running-back room with CMC and Mason injured
(6:45) Is there a silver lining to CMC injury?
(8:00) Guerendo’s great opportunity
(11:00) O-line options with Banks possibly headed for big payday
(26:00) Guerendo's history as WR up until college will help his adjustment
(29:00) Stopping the run will be key to 49ers resurgence this season

Matt Maiocco and Jennifer Lee Chan break down the 49ers’ second blowout loss in as many weeks and news that Christian McCaffrey could be out for the rest of the season with a PCL injury. Matt and Jennifer also dissect whether San Francisco can turn this season around after another demoralizing loss or if it is time to look ahead to next season.

(2:00) Christian McCaffrey exits game early with possible season-ending PCL injury

(6:30) After back-to-back blowouts, are the 49ers the worst team in the NFL right now?

(9:00) Analyzing George Kittle’s lack of involvement in Sunday’s loss to Bills

(15:30) Can 49ers bounce back from back-to-back demoralizing losses?

(20:30) Discussing similarities between 2024 and 2020 seasons

(24:15) 49ers will be facing significant roster decisions after 2024 season

49ers GM John Lynch sits down with Matt Maiocco to discuss San Francisco's subpar season so far and why Christian McCaffrey is ready to break out. Matt also chats with Jennifer Lee Chan and Carlos Ramirez to break down Brock Purdy's availability for the 49ers' crucial Sunday Night Football matchup against the Buffalo Bills.

Matt Maiocco and Jennifer Lee Chan discuss the 49ers' mounting injuries entering their prime-time matchup with the Bills on NBC's "Sunday Night Football," including a previously undisclosed ankle fracture to star linebacker Fred Warner. Matt and Jennifer also analyze which three players on offense and defense have performed lower or been available significantly less compared to their standout 2023 seasons. Later, Matt and Greg Papa discuss if inclement weather will play a role in Buffalo, as well as keys to San Francisco making the Week 13 matchup competitive.

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(1:00) 49ers injury updates

(10:00) Comparing 2023 49ers to 2024 team, which mathematically is still in the playoff hunt

(13:00) Offensive, defensive players whose production fell significantly between last season and this season

(22 :00) How inclement weather in Buffalo could affect SNF game

(24:00) Which backup QB should play if Purdy sits out again?

(32:00) Keys to 49ers coming out competitive vs. Bills

Matt Maiocco and Jennifer Lee Chan discuss how the 49ers struggled mightily in Week 12 against the Green Bay Packers. From miscues to mishaps and many missed tackles, Matt and Jennifer break down how the 49ers were out-performed on all three phases. Later, Matt and Jennifer assess if the 49ers can build any momentum down the final stretch of the season.

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(1:00) 49ers "embarrassed" by Packers, got "bullied"

(5:15) CMC's struggles continue in third game since returning

(15:15) Special teams again make ‘back-breaking’ miscues

(22:00) Can the 49ers' end with some semblance of momentum to end the season

(30:30) At lot of the 49ers' offseason plans, potential changes ride on the final six games