Matt Maiocco and Jennifer Lee Chan discuss who can replace rookie running back Isaac Guerendo's production if he can't overcome his sprained foot on a short week. Under the microscope this week, can Deebo Samuel shed the criticism and help the 49ers' offense repeat its high-octane performance vs. Chicago, or will backup Patrick Taylor Jr. emerge from anonymity as the 5th-string running back this season for San Francisco. Later, Matt and Greg Papa discuss how the 49ers' adjust their game plans and practice schedules on a short week and the possibility of linebacker Dre Greenlaw making his 2024 season debut in Week 15 vs. the Rams.

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(1:00) Must win territory, have to play desperation football
(3:30) Deebo a big topic of conversation this week, production down, but big opportunity in Week 15
(13:00) Injury Update – Big three going into this week Guerendo, Bosa, Trent are questionable
(14:00) Runnings back room depth chart
(17:00) If Greenlaw returns there will be a boost in the stands and on the field
(27:00) 18 teams in the NFL run Kyle’s offense now

Matt Maiocco and Jennifer Lee Chan analyze how the 49ers got back to their winning ways against the Bears behind an explosive offense and dominant defense. Matt and Jennifer discuss rookie running back Isaac Guerendo's two-touchdown performance and how the run game will shape up on a short week. Also, Matt and Jennifer look ahead to the 49ers' Thursday night showdown with division rival LA Rams and how San Francisco can get back to .500.

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(1:00) Recapping rookie RB Isaac Guerendo’s impressive performance
(4:15) Ji'Ayir Brown odd-man out of secondary with Hufanga back
(11:30) Injury updates on Guerendo's ankle, OL Ben Bartch's ankle
(17:30) Taking inventory of rest of NFC West Division results, remaining schedules
(21:30) Deommodore Lenoir's surprise team speech, showing leadership
(24:00) Rest of the season is about not spiraling into the offseason

Matt Maiocco and Jennifer Lee Chan break down the 49ers' injury crisis and which players will need to step up on Sunday and for the rest of the season. Also, Kyle Shanahan sits down with Greg Papa to detail what to expect from Isaac Guerendo and break down how San Francisco will defend Caleb Williams and the the Chicago Bears.